open for new plasmid ideas? that's all you had to say ^^
1. maybe make ultimate plasmids that can be found and used very sparingly, I.e empty everyone's ammo, or suck up all eve from everyone(not including hypos), or make yourself invulnerable and invisible, but incapable of attacking(allowing you to get out of a tight corner, or get into a good flanking spot)
2. for typical plasmids, are big daddys going to be more powerful then your average joe? maybe you could make some unique plasmids for countering them. you could throw in hypnotize big daddy, and make it either incapacitate him or make him ally you (i.e he can't shoot you, but he you don't control him to make it fair) or you could do some sort of extra damaging plasmid that effects only big daddy, with a long cd, and maybe make it somewhat unique so not everybody is spamming it on him. also, you could make like a super telekinesis of sorts, make it blast everything in front of the caster(I'm assuming you have loose doodads so as to use telekinesis) which damage whoever get hit by them, and for even more havoc make it blast the people themselves, or make it so they can't move. this of course would have to be rare and have either a long cd or limited amount of uses. why stop at telekinesis ? you could make a chain lightning thunder, or aoe fire, or a line of winter blast! maybe spawn an actual hive of bees that you put in your hand or something, and nearby enemies get the same effect as a regular swarm, and it stays forever, but goes on a limited number of people. you could just do more clones with target dummy, but maybe make the clone capable of using some weak plasmids, allowing you to throw off the enemy and dish a little damage. the list goes on for those sort of things
now for more unique plasmids...hmm..you have reload times? or ammo? if so, you could make a plasmid that instantly reloads your weapon, helpful for those long reload time weapons and when you need to shoot right there and now.
that's sall I got now, I could brainstorm some bioshock-esque names if any of them are of interest, but that takes a some considerate thinking and I don't want to waste that XD