I also experimented before with a Fighting Game with Wc3 WE. It is possible, maybe you should use wow models as they got many animations. I made it like Tekken with fighting a 2d fighting arena. As I made it for Singleplayer purposes I configured an AI to fight against and made it that strong that I wasn´t even able to beat it by myself ^^. The character where able to use attack, spell, defend + the arrow keys. For example pushing to the left while your char looked to the right made him do a dodge move, it worked quite well and the fights against the AI were very exciting.
So if you need help or want to know how I made my Trigger (GUI) concept, you can write me. But I will only give advices as I work on my own project the whole time.