Look for tutorials y you don't understand parts of this:
1. Create a rune item-type array (To store the type of runes you'll have)
2. Create a rune boolean array (Set to true if the rune is ON, set to false if rune has been picked)
3. Create a real array with X/Y of both rune locations.
4. Create a repeating timer that every 35 seconds checks if RuneBoolean is true/false. If It's true do nothing, if it's false, create the new rune (Random integer from 0 to MaxRunes of RuneArray) on the random X/Y stablished in the Real Array, and set RuneBoolean true.
5. When rune is picked, set RuneBoolean to false.
Additional:
6. Learn English.