If you need a place for the main city, make it somewhere accessible. Not much creeps or enemies since its a big city. Big cities mostly exceed economically and have a good cost of living. So make it look good, be accessible and make the city not meant for everyone.
You also need those essentials like blacksmiths, markets, etc. Good locations for it would be near the sea/ocean so it would be the fishing capital or somewhere where there are many resources. Maybe put some schools, Colosseum, Barracks for defense, also divide the city into different parts, each having a corresponding function or specialty like one part is the economically exceeding part, one is the barracks, defense area, one is the residential, one is the castle, etc.
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